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Article

Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system.

Oncogene - 1 Dec 2016

Varga M G, Shaffer C L, Sierra J C, Suarez G, Piazuelo M B, Whitaker M E, Romero-Gallo J, Krishna U S, Delgado A, Gomez M A, Good J A D, Almqvist F, Skaar E P, Correa P, Wilson K T, Hadjifrangiskou M, Peek R M

Abstract excerpt

Helicobacter pylori (H. pylori) is the strongest identified risk factor for gastric cancer, the third most common cause of cancer-related death worldwide. An H. pylori constituent that augments cancer risk is the strain-specific cag pathogenicity island, which encodes a type IV secretion system (T4SS) that translocates a pro-inflammatory and oncogenic protein, CagA, into epithelial cells. However, the majority of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27157617
DOI: 10.1038/onc.2016.158
PMCID: PMC5102820

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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