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Host immune response mediates changes in cagA copy number and virulence potential of Helicobacter pylori

15 Mar 2022

Abstract excerpt

Helicobacter pylori is the major risk factor for gastric cancer. H. pylori harboring the type IV secretion system (T4SS) and its effector CagA encoded on the cag pathogenicity Island (cagPAI) increases the risk. H. pylori PMSS1 has a multi-cagA genotype, modulating cagA copy number dynamically from zero to four copies. To examine the effect of the immune response on cagA copy number change, we utilized a mouse...

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PMID: 35289715
DOI: 10.1080/19490976.2022.2044721

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