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T4SS-dependent TLR5 activation by Helicobacter pylori infection

16 Dec 2019

Abstract excerpt

Abstract Toll-like receptor TLR5 recognizes a conserved domain, termed D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Highly virulent H. pylori strains possess a type IV secretion system (T4SS) for delivery of virulence factors into gastric epithelial cells. Here, we show that one of the H. pylori T4SS components, protein CagL, can act as a flagellin-independent...

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PMID: 31844047
DOI: 10.1038/s41467-019-13506-6

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