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Article

Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia.

BMC biology - 19 Oct 2016

Hnízda Aleš, Škerlová Jana, Fábry Milan, Pachl Petr, Šinalová Martina, Vrzal Lukáš, Man Petr, Novák Petr, Řezáčová Pavlína, Veverka Václav

Abstract excerpt

BACKGROUND: Relapsed acute lymphoblastic leukemia (ALL) is one of the main causes of mortality in childhood malignancies. Previous genetic studies demonstrated that chemoresistant ALL is driven by activating mutations in NT5C2, the gene encoding cytosolic 5´-nucleotidase (cN-II). However, molecular mechanisms underlying this hyperactivation are still unknown. Here, we present kinetic and structural properties of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27756303
DOI: 10.1186/s12915-016-0313-y
PMCID: PMC5070119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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