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Article

In silico identification of deleterious NT5C2 and PRPS1 mutations driving thiopurine resistance in relapsed acute lymphoblastic leukemia.

Cancer genetics - 1 Apr 2026

Sharma Ramita, Kudithipudi Jeeshitha, Singh Himanshu, Prabhu Dhamodharan, Vuree Sugunakar

Abstract excerpt

Relapse in Acute Lymphoblastic Leukemia (ALL) are often driven by multiple factors, including thiopurine drug-resistant mutations in NT5C2 and PRPS1. To determine the functional significance of these mutations, we employed comprehensive computational methods to assess their impact on protein stability, evolutionary conservation, and possible drug sensitivity, as well as molecular docking and simulations with 6-MP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41518974
DOI: 10.1016/j.cancergen.2026.01.001

Genes

NT5C2
PRPS1
TG

Variants

rs775844720
rs775844720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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In silico identification of deleterious NT5C2 and PRPS1 mutations driving thiopurine resistance in relapsed acute lymphoblastic leukemia.PMID 41518974Read ↗

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