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Article

Myelofibrosis: Genetic Characteristics and the Emerging Therapeutic Landscape.

Cancer research - 1 Mar 2022

Tefferi Ayalew, Gangat Naseema, Pardanani Animesh, Crispino John D

Abstract excerpt

Primary myelofibrosis (PMF) is one of three myeloproliferative neoplasms (MPN) that are morphologically and molecularly inter-related, the other two being polycythemia vera (PV) and essential thrombocythemia (ET). MPNs are characterized by JAK-STAT-activating JAK2, CALR, or MPL mutations that give rise to stem cell-derived clonal myeloproliferation, which is prone to leukemic and, in case of PV and ET, fibrotic...

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Identifiers

PMID: 34911786
DOI: 10.1158/0008-5472.CAN-21-2930
PMCID: PMC9306313

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