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Article

Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis.

Blood - 14 Aug 2014

Rumi Elisa, Pietra Daniela, Pascutto Cristiana, Guglielmelli Paola, Martínez-Trillos Alejandra, Casetti Ilaria, Colomer Dolors, Pieri Lisa, Pratcorona Marta, Rotunno Giada, Sant'Antonio Emanuela, Bellini Marta, Cavalloni Chiara, Mannarelli Carmela, Milanesi Chiara, Boveri Emanuela, Ferretti Virginia, Astori Cesare, Rosti Vittorio, Cervantes Francisco, Barosi Giovanni, Vannucchi Alessandro M, Cazzola Mario

Abstract excerpt

We studied the impact of driver mutations of JAK2, CALR, (calreticulin gene) or MPL on clinical course, leukemic transformation, and survival of patients with primary myelofibrosis (PMF). Of the 617 subjects studied, 399 (64.7%) carried JAK2 (V617F), 140 (22.7%) had a CALR exon 9 indel, 25 (4.0%) carried an MPL (W515) mutation, and 53 (8.6%) had nonmutated JAK2, CALR, and MPL (so-called triple-negative PMF)....

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Source

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Identifiers

PMID: 24986690
DOI: 10.1182/blood-2014-05-578435
PMCID: PMC4133481

Genes

CALR
JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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