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Article

Presence of triple positive driver mutations in JAK2, CALR and MPL in primary myelofibrosis: a case report and literature review.

Hematology (Amsterdam, Netherlands) - 1 Dec 2024

Zhao Long, Zhang Hao, Chen Juan, Ma Haizhen, Liu Bei

Abstract excerpt

BACKGROUND: Primary myelofibrosis (PMF) is the most advanced subtype among the classic Philadelphia chromosomenegative myeloproliferative neoplasms (MPNs). A majority of patients carry one of three mutually-exclusive somatic driver mutations: JAK2 (60-65%), CALR (20-25%), or MPL (5%). Co-occurrence of these mutations is rarely reported. Here we report a case with a triple positive combination of JAK2, CALR and...

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PMID: 39268974
DOI: 10.1080/16078454.2024.2402106

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