Triple-Negative Primary Myelofibrosis: A Bone Marrow Pathology Group Study.

doi:10.1016/j.modpat.2022.100016

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Article

Triple-Negative Primary Myelofibrosis: A Bone Marrow Pathology Group Study.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2023

Al-Ghamdi Yahya A, Lake Jonathan, Bagg Adam, Thakral Beenu, Wang Sa A, Bueso-Ramos Carlos, Masarova Lucia, Verstovsek Srdan, Rogers Heesun J, Hsi Eric D, Gralewski Jonathon H, Chabot-Richards Devon, George Tracy I, Rets Anton, Hasserjian Robert P, Weinberg Olga K, Parilla Megan, Arber Daniel A, Padilla Osvaldo, Orazi Attilio, Tam Wayne

Abstract excerpt

Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm driven by canonical gene mutations in JAK2, CALR, or MPL in >80% of the cases. PMF that lacks these canonical alterations is termed triple-negative PMF (TN-PMF). The pathologic and genetic characteristics of TN-PMF compared with those of conventional PMF with canonical driver mutations (DM-PMF) have not been well studied. We aimed to identify...

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