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CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen.

Genes - 11 Mar 2020

Xu Yuxin, Liu Hongmei, Pan Huilin, Wang Xinyue, Zhang Yuxin, Yao Bing, Li Nannan, Lai Liangxue, Li Zhanjun

Abstract excerpt

Hair growth and morphology are generally regulated by the hair cycle in mammals. Fibroblast Growth Factor 5 (FGF5), which is a hair cycle regulator, has a role in regulating the hair cycle during the transition from the anagen phase to the catagen phase, and a hereditary long hair phenotype has been widely reported when FGF5 is mutated in humans and other species. However, there has been no such report in...

Topics

Animals
CRISPR-Cas Systems
Exons
Fibroblast Growth Factor 5
Hair
Hair Follicle
Phenotype
RNA, Messenger
Rabbits

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32168764
DOI: 10.3390/genes11030297
PMCID: PMC7140871

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