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CRISPR/Cas9‐mediated loss of FGF5 function increases wool staple length in sheep

20 Jun 2017

Abstract excerpt

Fibroblast growth factor 5 (FGF5) regulates hair length in humans and a variety of other animals. To investigate whether FGF5 has similar effects in sheep, we used clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated 9 (Cas9) to generate loss-of-function mutations with the FGF5 gene in Chinese Merino sheep. A total of 16 lambs were identified with genetic mutations within the...

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PMID: 28631368
DOI: 10.1111/febs.14144

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