The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.

doi:10.1371/journal.pone.0164041

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Article

The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.

PloS one - 1 Jan 2016

Miller Suzanne, Henry Amanda P, Hodge Emily, Kheirallah Alexander K, Billington Charlotte K, Rimington Tracy L, Bhaker Sangita K, Obeidat Ma'en, Melén Erik, Merid Simon K, Swan Caroline, Gowland Catherine, Nelson Carl P, Stewart Ceri E, Bolton Charlotte E, Kilty Iain, Malarstig Anders, Parker Stuart G, Moffatt Miriam F, Wardlaw Andrew J, Hall Ian P, Sayers Ian

Abstract excerpt

INTRODUCTION: Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Receptor (AGER, encoding RAGE). We aimed to (i) characterise RAGE expression in the lung, (ii) identify AGER transcripts, (iii) ascertain if SNP rs2070600 (Gly82Ser C/T) is...

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Identifiers

PMID: 27755550
DOI: 10.1371/journal.pone.0164041
PMCID: PMC5068780

Genes

AGER
HMGB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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