Article
Complex tissue-specific patterns and distribution of multiple RAGE splice variants in different mammals.
Genome biology and evolution - 1 Jan 2013
López-Díez Raquel, Rastrojo Alberto, Villate Olatz, Aguado Begoña
Abstract excerpt
The receptor for advanced glycosylation end products (RAGE) is a multiligand receptor involved in diverse cell signaling pathways. Previous studies show that this gene expresses several splice variants in human, mouse, and dog. Alternative splicing (AS) plays an important role in expanding transcriptomic and proteomic diversity, and it has been related to disease. AS is also one of the main evolutionary...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- Genetic Variation
- Haplorhini
- Humans
- Mice
- Organ Specificity
- Protein Isoforms
- RNA, Messenger
- RNA, Untranslated
- Rats
- Receptor for Advanced Glycation End Products