Which immune cells matter? The immunopathogenesis of multiple sclerosis.

doi:10.1615/critrevimmunol.2013007453

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Article

Which immune cells matter? The immunopathogenesis of multiple sclerosis.

Critical reviews in immunology - 1 Jan 2013

Broux Bieke, Stinissen Piet, Hellings Niels

Abstract excerpt

Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is believed to be immune-mediated. While CD4+ T cells have been the main suspects for years, there is ample evidence that other immune cells (including those of the innate immune system) play a contributing or regulating role in this disease. After a general introduction, this review focuses on different immune cell subsets...

Topics

Adaptive Immunity
Animals
B-Lymphocytes
Genetic Predisposition to Disease
Humans
Immunity, Innate
Multiple Sclerosis
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 23971528
DOI: 10.1615/critrevimmunol.2013007453

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