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Article

B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains.

The American journal of pathology - 1 Dec 2016

Slot Linda M, Hoogeboom Robbert, Smit Laura A, Wormhoudt Thera A M, Biemond Bart J, Oud Monique E C M, Schilder-Tol Esther J M, Mulder André B, Jongejan Aldo, van Kampen Antoine H C, Kluin Philip M, Guikema Jeroen E J, Bende Richard J, van Noesel Carel J M

Abstract excerpt

Follicular lymphoma (FL) is an indolent B-cell non-Hodgkin lymphoma able to transform into germinal center-type diffuse large B-cell lymphoma. We describe four extraordinary cases of FL, which progressed to TdT+CD20- precursor B-lymphoblastic lymphoma (B-LBL). Fluorescence in situ hybridization analysis showed that all four B-LBLs had acquired a MYC translocation on transformation. Comparative genomic...

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Source

Identifiers

PMID: 27750045
DOI: 10.1016/j.ajpath.2016.07.027

Genes

CCND3
FMN2
MYC
NEB
SMARCA2
TNFRSF14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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