Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans.

doi:10.18632/aging.101067

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Article

Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans.

Aging - 13 Oct 2016

Liu Wanqing, Anstee Quentin M, Wang Xiaoliang, Gawrieh Samer, Gamazon Eric R, Athinarayanan Shaminie, Liu Yang-Lin, Darlay Rebecca, Cordell Heather J, Daly Ann K, Day Chris P, Chalasani Naga

Abstract excerpt

The increased expression of PNPLA3148M leads to hepatosteatosis in mice. This study aims to investigate the genetic control of hepatic PNPLA3 transcription and to explore its impact on NAFLD risk in humans. Through a locus-wide expression quantitative trait loci (eQTL) mapping in two human liver sample sets, a PNPLA3 intronic SNP, rs139051 A>G was identified as a significant eQTL (p = 6.6×10-8) influencing PNPLA3...

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PMID: 27744419
DOI: 10.18632/aging.101067
PMCID: PMC5310654

Genes

PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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