Article
Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study.
Liver international : official journal of the International Association for the Study of the Liver - 1 Mar 2011
Wagenknecht Lynne E, Palmer Nicholette D, Bowden Donald W, Rotter Jerome I, Norris Jill M, Ziegler Julie, Chen Yii-Der I, Haffner Steven, Scherzinger Ann, Langefeld Carl D
Abstract excerpt
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition, particularly among Hispanic Americans. A genetic variant in PNPLA3 (rs738409) has been identified as a strong predictor of hepatic fat content. AIMS: To confirm the association of this variant with NAFLD in two minority cohorts, Hispanic Americans and African Americans, in whom liver density was quantified by computed...
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