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Article

Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3.

Atherosclerosis - 1 Mar 2016

Oldoni Federico, Palmen Jutta, Giambartolomei Claudia, Howard Philip, Drenos Fotios, Plagnol Vincent, Humphries Steve E, Talmud Philippa J, Smith Andrew J P

Abstract excerpt

Genome-wide association studies have confirmed the involvement of non-coding angiopoietin-like 3 (ANGPTL3) gene variants with coronary artery disease, levels of low-density lipoprotein cholesterol (LDL-C), triglycerides and ANGPTL3 mRNA transcript. Extensive linkage disequilibrium at the locus, however, has hindered efforts to identify the potential functional variants. Using regulatory annotations from ENCODE,...

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Identifiers

PMID: 26800306
DOI: 10.1016/j.atherosclerosis.2015.12.009
PMCID: PMC4773290

Genes

ANGPTL3
DOCK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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