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Article

A genetic basis of mitochondrial DNAJA3 in nonalcoholic steatohepatitis-related hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Jan 2025

Chang Ching-Wen, Chen Yu-Syuan, Huang Chen-Hua, Lin Chao-Hsiung, Ng Wailap Victor, Chu Lichieh Julie, Trépo Eric, Zucman-Rossi Jessica, Siao Kevin, Maher Jacquelyn J, Chiew Men Yee, Chou Chih-Hung, Huang Hsien-Da, Teo Wan-Huai, Lee I-Shan, Lo Jeng-Fan, Wang Xin Wei

Abstract excerpt

BACKGROUND AND AIMS: NAFLD is the most common form of liver disease worldwide, but only a subset of individuals with NAFLD may progress to NASH. While NASH is an important etiology of HCC, the underlying mechanisms responsible for the conversion of NAFLD to NASH and then to HCC are poorly understood. We aimed to identify genetic risk genes that drive NASH and NASH-related HCC. APPROACH AND RESULTS: We searched...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 37870291
DOI: 10.1097/HEP.0000000000000637
PMCID: PMC11035488

Genes

DNAJA3
PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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