Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women.

doi:10.1038/s41591-023-02553-8

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Article

Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women.

Nature medicine - 1 Oct 2023

Cherubini Alessandro, Ostadreza Mahnoosh, Jamialahmadi Oveis, Pelusi Serena, Rrapaj Eniada, Casirati Elia, Passignani Giulia, Norouziesfahani Marjan, Sinopoli Elena, Baselli Guido, Meda Clara, Dongiovanni Paola, Dondossola Daniele, Youngson Neil, Tourna Aikaterini, Chokshi Shilpa, Bugianesi Elisabetta, Della Torre Sara, Prati Daniele, Romeo Stefano, Valenti Luca

Abstract excerpt

Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of liver disease and the prevalence is rising, especially in women. Although during reproductive age women are protected against FLD, for still unknown and understudied reasons some develop rapidly progressive disease at the menopause. The patatin-like phospholipase domain-containing 3 (PNPLA3) p.I148M variant accounts for the largest...

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PMID: 37749332
DOI: 10.1038/s41591-023-02553-8
PMCID: PMC10579099

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