Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression.

Rheumatology (Oxford, England) - 1 Jan 2017

Nakayama Wakana, Jinnin Masatoshi, Tomizawa Yukiko, Nakamura Kayo, Kudo Hideo, Inoue Kuniko, Makino Katsunari, Honda Noritoshi, Kajihara Ikko, Fukushima Satoshi, Ihn Hironobu

Abstract excerpt

OBJECTIVES: The overexpression of IL-12 family cytokines is implicated in the pathogenesis of SSc, but their exact role is still unclear. The aim of this study was to investigate the regulation of extracellular matrix expression by IL-23 and its contribution to the phenotype of SSc. METHODS: The mRNA expression was determined by PCR array and real-time PCR. The expression levels of proteins were determined by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Bleomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type I

Share to Connective Tissue Growth Factor

Share to Extracellular Matrix

Share to Fibrosis

Share to Interleukin-12

Share to Interleukin-23

Source

Identifiers

PMID: 27744356
DOI: 10.1093/rheumatology/kew336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression.PMID 27744356Read ↗

Decreased interleukin-20 expression in scleroderma skin contributes to cutaneous fibrosis.Semantic proximity Read ↗

A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast TransitionSemantic proximity Read ↗

MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cellsSemantic proximity Read ↗

The Downregulation of microRNA let-7a Contributes to the Excessive Expression of Type I Collagen in Systemic and Localized SclerodermaSemantic proximity Read ↗

BMSC-Derived Exosomes Intervened the Pathogenic Changes of Scleroderma in Mouse Through Its microRNAsSemantic proximity Read ↗

MicroRNAs: their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in sclerodermaSemantic proximity Read ↗

MicroRNA-27a-3p inhibits lung and skin fibrosis of systemic sclerosis by negatively regulating SPP1Semantic proximity Read ↗

TGF-β-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts.Semantic proximity Read ↗

Integration of microRNA and mRNA expression profiles in the skin of systemic sclerosis patients.Semantic proximity Read ↗

Transforming growth factor-beta in systemic sclerosis sclerodermaSemantic proximity Read ↗

MicroRNA-29: a potential therapeutic target for systemic sclerosisSemantic proximity Read ↗

Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor βSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.