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MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells

29 Jul 2024

Abstract excerpt

Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the skin and multiple vital organs, but the immunological pathogenesis of SSc remains unclear. We show here that miR-19b promotes Th9 cells that exacerbate SSc. Specifically, miR-19b and interleukin (IL)-9 increase in CD4 + T cells in experimental SSc in mice induced with bleomycin. Inhibiting miR-19b reduces Th9 cells and...

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PMID: 39083380
DOI: 10.1016/j.celrep.2024.114565

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