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MicroRNAs: their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma

20 Sept 2013

Abstract excerpt

miRNAs are important post-transcriptional regulators. The aberrant expression of miRNAs is strongly associated with the initiation and progression of pathophysiologic processes in a wide range of human diseases. Scleroderma (systemic sclerosis; SSc) is a highly heterogeneous autoimmune disease that includes the progressive fibrotic replacement of normal tissue architecture in multiple organs. Our previous studies...

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PMID: 24052166
DOI: 10.1038/emm.2013.71

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