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Article

TGF-β-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2012

Honda Noritoshi, Jinnin Masatoshi, Kajihara Ikko, Makino Takamitsu, Makino Katsunari, Masuguchi Shinichi, Fukushima Satoshi, Okamoto Yoshinobu, Hasegawa Minoru, Fujimoto Manabu, Ihn Hironobu

Abstract excerpt

Previous reports indicated the significance of the TGF-β signaling in the pathogenesis of systemic sclerosis. We tried to evaluate the possibility that microRNAs (miRNAs) play a part in the type I collagen upregulation seen in normal fibroblasts stimulated with exogenous TGF-β and systemic sclerosis (SSc) fibroblasts. miRNA expression profile was evaluated by miRNA PCR array and real-time PCR. The protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22379029
DOI: 10.4049/jimmunol.1100876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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