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Article

IFNα-mediated remodeling of endothelial cells in the bone marrow niche.

Haematologica - 1 Mar 2017

Prendergast Áine M, Kuck Andrea, van Essen Mieke, Haas Simon, Blaszkiewicz Sandra, Essers Marieke A G

Abstract excerpt

In the bone marrow, endothelial cells are a major component of the hematopoietic stem cell vascular niche and are a first line of defense against inflammatory stress and infection. The primary response of an organism to infection involves the synthesis of immune-modulatory cytokines, including interferon alpha. In the bone marrow, interferon alpha induces rapid cell cycle entry of hematopoietic stem cells in vivo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27742772
DOI: 10.3324/haematol.2016.151209
PMCID: PMC5394972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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