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Article

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate

14 Oct 2016

Abstract excerpt

TGFβs act through canonical and non-canonical pathways, and canonical signals are transduced via Smad2 and Smad3. However, the contribution of canonical vs. non-canonical pathways in cartilage is unknown because the role of Smad2 in chondrogenesis has not been investigated in vivo. Therefore, we analyzed mice in which Smad2 is deleted in cartilage (Smad2CKO), global Smad3-/- mutants, and crosses of these strains....

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PMID: 27741240
DOI: 10.1371/journal.pgen.1006352

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