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Article

Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia.

European journal of clinical pharmacology - 1 Dec 2012

Varatharajan Savitha, Abraham Ajay, Zhang Wei, Shaji R V, Ahmed Rayaz, Abraham Aby, George Biju, Srivastava Alok, Chandy Mammen, Mathews Vikram, Balasubramanian Poonkuzhali

Abstract excerpt

PURPOSE: The present study aimed to investigate the role of expression of daunorubicin-metabolizing enzymes carbonyl reductase 1 and 3 (CBR1 and CBR3) on the in vitro cytotoxicity of daunorubicin in primary acute myeloid leukemia (AML) cells and the effect of genetic variants in CBR1 and CBR3 on the plasma pharmacokinetics of daunorubicin and daunorubicinol (DOL) in AML patients. METHODS: RNA expression of CBR1...

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Source

Identifiers

PMID: 22562609
DOI: 10.1007/s00228-012-1291-9

Genes

CBR1
CBR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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