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Article

Role of Genetic Polymorphisms of Deoxycytidine Kinase and Cytidine Deaminase to Predict Risk of Death in Children with Acute Myeloid Leukemia.

BioMed research international - 1 Jan 2015

Medina-Sanson Aurora, Ramírez-Pacheco Arturo, Moreno-Guerrero Silvia Selene, Dorantes-Acosta Elisa María, Sánchez-Preza Metzeri, Reyes-López Alfonso

Abstract excerpt

Cytarabine is one of the most effective antineoplastic agents among those used for the treatment of acute myeloid leukemia. However, some patients develop resistance and/or severe side effects to the drug, which may interfere with the efficacy of the treatment. The polymorphisms of some Ara-C metabolizing enzymes seem to affect outcome and toxicity in AML patients receiving cytarabine. We conducted this study in...

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Identifiers

PMID: 26090398
DOI: 10.1155/2015/309491
PMCID: PMC4450239

Genes

CDA

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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