Article
Role of Genetic Polymorphisms of Deoxycytidine Kinase and Cytidine Deaminase to Predict Risk of Death in Children with Acute Myeloid Leukemia.
BioMed research international - 1 Jan 2015
Medina-Sanson Aurora, Ramírez-Pacheco Arturo, Moreno-Guerrero Silvia Selene, Dorantes-Acosta Elisa María, Sánchez-Preza Metzeri, Reyes-López Alfonso
Abstract excerpt
Cytarabine is one of the most effective antineoplastic agents among those used for the treatment of acute myeloid leukemia. However, some patients develop resistance and/or severe side effects to the drug, which may interfere with the efficacy of the treatment. The polymorphisms of some Ara-C metabolizing enzymes seem to affect outcome and toxicity in AML patients receiving cytarabine. We conducted this study in...
Topics
- Adolescent
- Child
- Child, Preschool
- Cytidine Deaminase
- Death
- Deoxycytidine Kinase
- Drug Resistance, Neoplasm
- Female
- Genotype
- Humans
- Infant
- Leukemia, Myeloid, Acute
- Male