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Article

Inherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia.

Clinical pharmacology and therapeutics - 1 Jun 2016

Drenberg C D, Paugh S W, Pounds S B, Shi L, Orwick S J, Li L, Hu S, Gibson A A, Ribeiro R C, Rubnitz J E, Evans W E, Sparreboom A, Baker S D

Abstract excerpt

Using broad interrogation of clinically relevant drug absorption, distribution, metabolism, and excretion (ADME) genes on the DMET platform, we identified a genetic variant in SLCO1B1 (rs2291075; c.597C>T), encoding the transporter OATP1B1, associated with event-free (P = 0.006, hazard ratio = 1.74) and overall survival (P = 0.012, hazard ratio = 1.85) in children with de novo acute myeloid leukemia (AML). Lack...

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Source

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Identifiers

PMID: 26663398
DOI: 10.1002/cpt.315
PMCID: PMC4898266

Variants

rs2291075
rs4149056
rs2291075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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