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Article

Association of ABCB1 polymorphisms with the efficacy of ondansetron in chemotherapy-induced nausea and vomiting.

Clinical therapeutics - 1 Aug 2014

He Hui, Yin Ji-Ye, Xu Ya-Jing, Li Xi, Zhang Yu, Liu Zhuo-Gang, Zhou Fan, Zhai Ming, Li Yan, Li Xiang-Ping, Wang Ying, Zhou Hong-Hao, Liu Zhao-Qian

Abstract excerpt

PURPOSE: Resistance to the antiemetic ondansetron is still a major problem resulting in discomfort and poor compliance with chemotherapy in acute myeloid leukemia (AML) patients. Based on our hypothesis that this clinical resistance to ondansetron is associated with ABCB1 genetic polymorphisms, we investigated whether ABCB1 gene variations affect the efficacy of ondansetron in chemotherapy-induced nausea and...

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Share to Antimetabolites, Antineoplastic
Share to Antineoplastic Combined Chemotherapy Protocols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B

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Share to Cytochrome P-450 CYP2D6

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Source

Identifiers

PMID: 25012726
DOI: 10.1016/j.clinthera.2014.06.016

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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