Article
MicroRNA let-7, T Cells, and Patient Survival in Colorectal Cancer.
Cancer immunology research - 1 Nov 2016
Dou Ruoxu, Nishihara Reiko, Cao Yin, Hamada Tsuyoshi, Mima Kosuke, Masuda Atsuhiro, Masugi Yohei, Shi Yan, Gu Mancang, Li Wanwan, da Silva Annacarolina, Nosho Katsuhiko, Zhang Xuehong, Meyerhardt Jeffrey A, Giovannucci Edward L, Chan Andrew T, Fuchs Charles S, Qian Zhi Rong, Ogino Shuji
Abstract excerpt
Experimental evidence suggests that the let-7 family of noncoding RNAs suppresses adaptive immune responses, contributing to immune evasion by the tumor. We hypothesized that the amount of let-7a and let-7b expression in colorectal carcinoma might be associated with limited T-lymphocyte infiltrates in the tumor microenvironment and worse clinical outcome. Utilizing the molecular pathological epidemiology...
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