Article
Fusobacterium nucleatum and T Cells in Colorectal Carcinoma.
JAMA oncology - 1 Aug 2015
Mima Kosuke, Sukawa Yasutaka, Nishihara Reiko, Qian Zhi Rong, Yamauchi Mai, Inamura Kentaro, Kim Sun A, Masuda Atsuhiro, Nowak Jonathan A, Nosho Katsuhiko, Kostic Aleksandar D, Giannakis Marios, Watanabe Hideo, Bullman Susan, Milner Danny A, Harris Curtis C, Giovannucci Edward, Garraway Levi A, Freeman Gordon J, Dranoff Glenn, Chan Andrew T, Garrett Wendy S, Huttenhower Curtis, Fuchs Charles S, Ogino Shuji
Abstract excerpt
IMPORTANCE: Evidence indicates a complex link between gut microbiome, immunity, and intestinal tumorigenesis. To target the microbiota and immunity for colorectal cancer prevention and therapy, a better understanding of the relationship between microorganisms and immune cells in the tumor microenvironment is needed. Experimental evidence suggests that Fusobacterium nucleatum may promote colonic neoplasia...
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