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Article

High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease.

The oncologist - 1 Jan 2012

Ruzzo Annamaria, Graziano Francesco, Vincenzi Bruno, Canestrari Emanuele, Perrone Giuseppe, Galluccio Nadia, Catalano Vincenzo, Loupakis Fotios, Rabitti Carla, Santini Daniele, Tonini Giuseppe, Fiorentini Giammaria, Rossi David, Falcone Alfredo, Magnani Mauro

Abstract excerpt

Preclinical and experimental data in vivo indicate that Lethal-7 (Let-7) microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations. We quantified the Let-7a isoform in KRAS-mutated colorectal carcinomas from patients who received salvage cetuximab plus irinotecan. The study population was retrospectively identified among metastatic colorectal cancer patients who underwent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22584434
DOI: 10.1634/theoncologist.2012-0081
PMCID: PMC3380881

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease.PMID 22584434Read ↗

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