Article
Mutation location on the RAS oncogene affects pathologic features and survival after resection of colorectal liver metastases.
Cancer - 15 Feb 2017
Frankel Timothy L, Vakiani Efsevia, Nathan Hari, DeMatteo Ronald P, Kingham T Peter, Allen Peter J, Jarnagin William R, Kemeny Nancy E, Solit David B, D'Angelica Michael I
Abstract excerpt
BACKGROUND: In the past 3 decades, a better understanding of gene mutations and their role in carcinogenesis has led to improvement in our ability to treat patients with metastatic disease. The objective of the current study was to determine whether the location of a driver mutation within an affected gene impacts the biology of metastatic colorectal cancer. METHODS: DNA was collected from 165 randomly selected...
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