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Article

Somatic Mutations in Surgically Treated Colorectal Liver Metastases: An Overview.

Cells - 14 Apr 2024

Wang Jane, Botvinov Julia, Bhatt Aarshvi Jahnvi, Beyer Katharina, Kreis Martin E, Adam Mohamed, Alseidi Adnan, Margonis Georgios Antonios

Abstract excerpt

Colorectal cancer is the second most common cause of cancer death in the United States, and up to half of patients develop colorectal liver metastases (CRLMs). Notably, somatic genetic mutations, such as mutations in RAS, BRAF, mismatch repair (MMR) genes, TP53, and SMAD4, have been shown to play a prognostic role in patients with CRLM. This review summarizes and appraises the current literature regarding the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38667294
DOI: 10.3390/cells13080679
PMCID: PMC11049420

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