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Article

Generation and Analysis of CCM Phenotypes in C. elegans.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Popiel Evelyn, Derry William Brent

Abstract excerpt

This chapter presents methods for exploiting the powerful tools available in the nematode worm Caenorhabditis elegans to understand the in vivo functions of cerebral cavernous malformation (CCM) genes and the organization of their associated signaling pathways. Included are methods for assessing phenotypes caused by loss-of-function mutations in the worm CCM genes kri-1 and ccm-3, CRISPR-based gene editing...

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PMID: 32524554
DOI: 10.1007/978-1-0716-0640-7_15

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