Article
Generation of Cerebral Cavernous Malformation in Neonatal Mouse Models Using Inducible Cre-LoxP Strategy.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Choi Jaesung P, Zheng Xiangjian
Abstract excerpt
Mutations in the CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation (CCM) in humans. Neonatal mouse models of CCM disease have been established by deleting any one of the Ccm genes. These mouse models provide invaluable in vivo disease model to investigate molecular mechanisms and therapeutic approaches for the disease. Here, we describe detailed methodology to generate CCM...
Topics
- Alleles
- Animals
- Apoptosis Regulatory Proteins
- Disease Models, Animal
- Genotype
- Hemangioma, Cavernous, Central Nervous System
- Homologous Recombination
- Integrases
- Mice
- Mice, Knockout
- Mice, Transgenic