Article

Integrated Multi-omics Reveals Key Molecular Drivers and Therapeutic Strategies in a Spontaneous Cutaneous Squamous Cell Carcinoma Model of Macaques

2026-05-15

Abstract excerpt

<title>Abstract</title> <p>Skin cancer, especially cutaneous squamous cell carcinoma (cSCC), remains a major global health problem. Here, we report a spontaneous macaque cSCC model (5/2752 incidence; 80% mortality) that reproduces key human cSCC features. Tumors show well-differentiated squamous morphology, expression of squamous lineage markers (p63, CK5/6), and elevated Ki-67 proliferation indices. We apply who...

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Literature Corpus work: d9841606-e2e5-5577-863a-bb182de720a6
DOI: 10.21203/rs.3.rs-8987244/v1

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