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Article

Whole Chromosome Instability induces senescence and promotes SASP.

Scientific reports - 12 Oct 2016

Andriani Grasiella Angelina, Almeida Vinnycius Pereira, Faggioli Francesca, Mauro Maurizio, Tsai Wanxia Li, Santambrogio Laura, Maslov Alexander, Gadina Massimo, Campisi Judith, Vijg Jan, Montagna Cristina

Abstract excerpt

Age-related accumulation of ploidy changes is associated with decreased expression of genes controlling chromosome segregation and cohesin functions. To determine the consequences of whole chromosome instability (W-CIN) we down-regulated the spindle assembly checkpoint component BUB1 and the mitotic cohesin SMC1A, and used four-color-interphase-FISH coupled with BrdU incorporation and analyses of senescence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomal Proteins, Non-Histone

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Share to In Situ Hybridization, Fluorescence

Share to Structural Maintenance of Chromosome Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 27731420
DOI: 10.1038/srep35218
PMCID: PMC5059742

Genes

BUB1
CCL2
CCL27
CXCL8
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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