Article
Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients.
Oncotarget - 8 Nov 2016
van den Broek Evert, Krijgsman Oscar, Sie Daoud, Tijssen Marianne, Mongera Sandra, van de Wiel Mark A, Belt Eric J Th, den Uil Sjoerd H, Bril Herman, Stockmann Hein B A C, Ylstra Bauke, Carvalho Beatriz, Meijer Gerrit A, Fijneman Remond J A
Abstract excerpt
Tumor profiling of DNA alterations, i.e. gene point mutations, somatic copy number aberrations (CNAs) and structural variants (SVs), improves insight into the molecular pathology of cancer and clinical outcome. Here, associations between genomic aberrations and disease recurrence in stage II and III colon cancers were investigated. A series of 114 stage II and III microsatellite stable colon cancer samples were...
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