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Article

Early genetic aberrations in patients with sporadic colorectal cancer.

Molecular carcinogenesis - 1 Jan 2018

Druliner Brooke R, Ruan Xiaoyang, Sicotte Hugues, O'Brien Daniel, Liu Hongfang, Kocher Jean-Pierre A, Boardman Lisa

Abstract excerpt

Chromosome instability (CIN) is widely observed in both sporadic and hereditary colorectal cancer (CRC). Defects in APC and WNT signaling are primarily associated with CIN in hereditary CRC, but the genetic causes for CIN in sporadic CRC remain elusive. Using high-density SNP array and exome data from The Cancer Genome Atlas (TCGA), we characterized loss of heterozygosity (LOH) and copy number variation (CNV) in...

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Source

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Identifiers

PMID: 28926134
DOI: 10.1002/mc.22738
PMCID: PMC5716916

Genes

APC
BRAF
CTNNB1
DCC
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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