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Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days

7 Oct 2016

Abstract excerpt

Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme activity limits their use in studies that require a prolonged xenobiotic exposure. The aim of the study was to extend the viability and function of hPCLS to 5 days of incubation. hPCLS were incubated in two media developed for long-term culture of...

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Share to Drug-Induced Hepatotoxicity and Protection
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PMID: 27717970
DOI: 10.1007/s00204-016-1865-x

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