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The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human

8 May 2012

Abstract excerpt

INTRODUCTION: HepaRG is a unique cell line showing a great plasticity, which differentiates to both canaliculae-like and hepatocyte-like cells. The long-term stability of key cell functions, for example, the drug-metabolizing cytochrome P450 (CYP) enzyme activities, in culture is especially useful in drug metabolism, disposition and toxicity studies. AREAS COVERED: This review describes features of the HepaRG...

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PMID: 22568886
DOI: 10.1517/17425255.2012.685159

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