Article
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Chemical research in toxicology - 21 Mar 2016
Vatakuti Suresh, Pennings Jeroen L A, Gore Emilia, Olinga Peter, Groothuis Geny M M
Abstract excerpt
Human toxicity screening is an important stage in the development of safe drug candidates. Hepatotoxicity is one of the major reasons for the withdrawal of drugs from the market because the liver is the major organ involved in drug metabolism, and it can generate toxic metabolites. There is a need to screen molecules for drug-induced hepatotoxicity in humans at an earlier stage. Transcriptomics is a technique...
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