Article
Behavioural endophenotypes in mice lacking the auxiliary GABAB receptor subunit KCTD16.
Behavioural brain research - 15 Jan 2017
Cathomas Flurin, Sigrist Hannes, Schmid Luca, Seifritz Erich, Gassmann Martin, Bettler Bernhard, Pryce Christopher R
Abstract excerpt
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain and is implicated in the pathophysiology of a number of neuropsychiatric disorders. The GABAB receptors are G-protein coupled receptors consisting of principle subunits and auxiliary potassium channel tetramerization domain (KCTD) subunits. The KCTD subunits 8, 12, 12b and 16 are cytosolic proteins that determine the kinetics of...
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