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Article

INPP4B is an oncogenic regulator in human colon cancer

28 Sept 2015

Abstract excerpt

Inositol polyphosphate 4-phosphatase type II (INPP4B) negatively regulates phosphatidylinositol 3-kinase signaling and is a tumor suppressor in some types of cancers. However, we have found that it is frequently upregulated in human colon cancer cells. Here we show that silencing of INPP4B blocks activation of Akt and serum- and glucocorticoid-regulated kinase 3 (SGK3), inhibits colon cancer cell proliferation...

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PMID: 26411369
DOI: 10.1038/onc.2015.361

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