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Article

Importance of rare gene copy number alterations for personalized tumor characterization and survival analysis.

Genome biology - 3 Oct 2016

Seifert Michael, Friedrich Betty, Beyer Andreas

Abstract excerpt

It has proven exceedingly difficult to ascertain rare copy number alterations (CNAs) that may have strong effects in individual tumors. We show that a regulatory network inferred from gene expression and gene copy number data of 768 human cancer cell lines can be used to quantify the impact of patient-specific CNAs on survival signature genes. A focused analysis of tumors from six tissues reveals that rare...

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Identifiers

PMID: 27716417
DOI: 10.1186/s13059-016-1058-1
PMCID: PMC5046221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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