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Article

Chronic Pseudomonas aeruginosa infection-induced chronic bronchitis and emphysematous changes in CCSP-deficient mice.

International journal of chronic obstructive pulmonary disease - 1 Jan 2016

Matsumoto Takemasa, Fujita Masaki, Hirano Ryosuke, Uchino Junji, Tajiri Yukari, Fukuyama Satoru, Morimoto Yasuo, Watanabe Kentaro

Abstract excerpt

The club cell secretory protein (CCSP) is a regulator of lung inflammation following acute respiratory infection or lung injury. Recently, the relationship between CCSP and COPD has been reported. Since COPD results from an abnormal inflammatory response, we hypothesized that CCSP could have a protective role against chronic inflammation-induced lung damage. To address this issue, the pathophysiology of chronic...

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Identifiers

PMID: 27703342
DOI: 10.2147/COPD.S113707
PMCID: PMC5036550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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