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Contribution of Pseudomonas aeruginosa − mediated club cell necroptosis to the bias of type 17 inflammation and steroid insensitivity in asthma

21 Oct 2024

Abstract excerpt

The role of opportunistic bacteria infection in the progression of asthma that PA infection promotes cellular CYP450 activation to mediate club cell necroptosis for DAMPs release and subsequent type 17 immune response and steroid resistance. In the rest of club cells, E-cadherin / β-catenin signaling was activated to regulate goblet metaplasia and mucus hypersecretion. Both mechanisms contribute to asthma...

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PMID: 39442871
DOI: 10.1016/j.jare.2024.10.020

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