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Article

Up-regulation of surfactant protein production in a mouse model of secondary pulmonary alveolar proteinosis.

American journal of respiratory cell and molecular biology - 1 May 2009

Shibasaki Masataka, Hashimoto Katsunori, Okamoto Masakazu, Hayashi Yuta, Imaizumi Kazuyoshi, Hashimoto Naozumi, Ozaki Nobuaki, Yokoi Toyoharu, Takagi Kenzo, Hasegawa Yoshinori, Shimokata Kaoru, Kawabe Tsutomu

Abstract excerpt

Although Pneumocystis infection might be one of the causes of secondary pulmonary alveolar proteinosis (PAP), the mechanism of its pathogenesis is uncertain. We analyzed a mouse model of secondary PAP resulting from Pneumocystis infection using mice deficient in CD40 (CD40KO), and evaluated the mechanism of the pathogenesis of secondary PAP from the viewpoint of surfactant-associated protein (SP) homeostasis, the...

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Identifiers

PMID: 18931325
DOI: 10.1165/rcmb.2008-0103OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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